Elimination half-life was 15.40 ± 5.80 h, and clearance was 5876 ± 699 (mL/kg/min). Clinical safety of TAM was determined over a 7-day course ofAnother important metabolite is 4-hydroxy-tamoxifen (4-OH TAM), which is generated by the action of the CYP2D6 isoforms and to a lesser extent...