19 Jul 2017 Prilosec and Zantac both reduce acid levels in the stomach to relieve symptoms of acid Prilosec vs. Zantac is a brand name for a different generic drug, ranitidine. . Prescribing information: Zantac 150, Zantac 300, Zantac 25, Zantac. Nexium and Prilosec are both similar drugs used...