Isotretinoin, also known as 13-cis-retinoic acid is a medication primarily used to treat severe .. Isotretinoin has a low affinity for retinoic acid receptors (RAR) and retinoid X receptors (RXR) the mean ±SD elimination half-life (t1/2) of isotretinoin and 4-oxo-isotretinoin were 21.0 ± 8.2...