Subjective sleep disturbance is common in SMS, corroborated by objective abnormalities on polysomnography [Greenberg et al., 1991, 1996].SMS deletion patients have been reported to have an inverted circadian rhythm of melatonin [De Leersnyder et al., 2001a; Potocki et al., 2000]. Behavioral problems correlated with the inverted circadian rhythm of melatonin. Conclusion:...