<span class=" fc-2nd">Sep 17, 2014 · </span> Can vicodin affect the health of a mans sperm? Answer. Wiki User September 17, 2014 7:55PM. Many drugs affect the production and motility of human sperm. Vicodin has been proven to lower the <span class=" fc-2nd">Nov 16, 2005 · </span> To the extent...