<span class=" fc-2nd">Nov 14, 2017 · </span> DESCRIPTION. Climara , is designed to release estradiol continuously upon application to intact skin. Six systems are available to provide nominal in vivo delivery of 0.025, 0.0375, 0.05, 0.06, 0.075 or 0.1 mg respectively of estradiol per day. Estradiol...