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- cialis and viagra sales The following parameters were calculated for tadalafil maximum observed plasma concentration C max ; time of C max t max , terminal elimination rate constant О» z and half-life t 1 2 , area under the plasma concentration time curve extrapolated to infinite time AUC , AUC within a 24-h dosing interval AUC П„ , oral clearance CL F , and apparent volume of distribution during the terminal elimination phase V z F